Wednesday, December 24, 2014

The effects of Viagra and weight training increases

Everyone knows that Viagra is taken in violation of erectile function in men. Today, however, it began to be used in the environment of bodybuilders and athletes

However, most bodybuilders are not concerned with the question: how to increase potency, but the drug they use for Pumping. The fact is that the active ingredient of Viagra (Sildenafil), enhances blood flow to muscles, which increases endurance thereby to achieve good results.

Bodybuilder can lift more weight, perform more reps with and approach than usual. Thus, coefficient useful weight training increases, thanks to the more intense muscle groups. opinion that Viagra is another donor of nitrogen. Currently, the organization that fights against doping explores the drug Viagra on athletic performance. If in the course of the experiments will still be shown that Viagra has a great contribution to athletic performance, the drug will be banned in speed and power sports. Bodybuilding such bans probably will not be threatened, as Viagra has no adverse impact on health. With minimal adverse events Viagra also has a positive effect on the heart, improves circulation and slightly reduces blood pressure.

Favorably to steroids and anabolic steroids, Viagra has no effect on the human body is harmful. It should be noted that an erection when using the drug only appears to stimulate sexual arousal. Another very popular among bodybuilders drug – Cialis. The active substance is analogous to the Cialis (Tadalafil), Sildenafil (Viagra). Blood flow to muscle is dramatically increased during high intensity exercise. The increase in blood flow serves to enhance the delivery of oxygen to active muscle cells and to increase the removal of lactate. This phenomenon is all too familiar to bodybuilders.  Viagra (Sildenafil Citrate): a refresher cours. Rest assured, this won’t happen. Sildenafil, at recommended doses, has no effect on erectile tissue in the absence of sexual stimulation. If you don’t normally find yourself sporting a woody as you step out on stage, you have nothing to worry about. Besides, you can always experiment before hand so you know what to expect (e.g. blood pressure changes). Now, back to the science of this little blue pill. Viagra is the citrate salt of Sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE5). A phosphodiesterase is a phosphatase (as from snake venom) that acts on diesters (like some nucleotides) to hydrolyze only one of the two ester groups. In target cells, phosphodiesterase acts to hydrolyze cGMP and cAMP into inactive fragments, thus shutting down the second messenger cascade. A phosphodiesterase-inhibitor is a molecule that inhibits the action of phosphodiesterase. This allows cGMP (or cAMP depending on the type of phosphodiesterase) to remain in active form and thus extends or prolongs the activity of the cascade. This is part of the rationale for using caffeine, a well-known phosphodiesterase-inhibitor, with ephedrine. In working muscles, nitric oxide (NO) activates the enzyme guanylate cyclase, which results in increased levels of cGMP, producing smooth muscle relaxation of blood vessel walls. This causes vasodilation. Sildenafil has no direct relaxant effect on smooth muscle alone, but enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP. For example, when hypoxia and/or lactate formation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the blood vessels, resulting in vasodilation. Once again, Sildenafil at recommended doses has no effect on penile tissue in the absence of sexual stimulation. Keep in mind that Sildenafil does not change the way lifting weights causes muscle pump either, it only enhances it.
There are several reasons why the pump you get back stage is far from dramatic. Getting a good pump depends in large part on lactate  formation by the working muscles. As your muscles are forced to work anaerobically, lactic acid is formed triggering a series of signals that dilate blood vessels leading to the muscle. A muscle adapted to caloric restriction shifts its preferred fuel from carbs to fatty acids and ketones, neither of which generates lactate when used for fuel. So while training on a low calorie and especially a low carb diet, lactate induced muscle blood flow is reduced compared to normal well-fed conditions. On the day of the show you want to look lean but with full muscle bellies. The only way to do this is to be in a state of good hydration, loaded with glycogen, have restored muscle triglyceride levels, and have a decent pump when you step on stage for the morning prejudging. Hydration, glycogen and muscle triglycerides will have to wait for another time, but getting a pump just got a little easier. Because NO triggers vasodilation in skeletal muscle vasculature, Viagra will increase the ability to get and maintain muscle pump by inhibiting PDE-5 production

Wednesday, December 17, 2014

Why Viagra is a great workout partner for bodybuilders

Viagra, first studied as an aid for hypertension, remedies erectile dysfunction by relaxing blood vessels in the penis. Athletes have found plenty of other reasons to embrace Vitamin V, though. Romano said many athletes take Viagra with anabolic steroids before a workout, hoping Viagra's ability to dilate blood vessels will help deliver the anabolics to their various muscle groups.

"The object of nutrient delivery is to get as much of it in the muscles ahead of time as possible," said Romano, who said he used Viagra for that reason. "You want to fortify the blood with whatever you're going to pump in there. Viagra is tailor-made for that because you're slamming in all kinds of amino acids and whatever else, then expanding the muscles and pumping it in there." Athletes are notorious for taking any pill or potion that seems to boost their performances, but research indicates Viagra is more than just a fad. Kenneth Rundell, a respiratory researcher at Marywood University in Scranton, Pa., said Viagra could increase stamina for athletes who compete at oxygen-poor high elevations.

"Any sport that's primarily an aerobic sport would benefit - cross-country skiers, cyclists, marathoners, 10K runners, 5K runners," he said. For a 2006 study published in the Journal of Applied Physiology, scientists using trained cyclists at high altitudes as test subjects found the drug had a similar effect on the lungs as it did on the penis, improving blood flow and moving more oxygen to muscles. Other athletes count on Viagra to kick-start their sex lives.

Long-term steroid use, says Gary Wadler, a Long Island physician and an adviser to the World Anti-Doping Agency, causes testicular atrophy, which leads to impotence.

"That may be why these guys started using it in the first place," said Michael Dusa, a Hamden, Conn., chiropractor who treats athletes.

"I suspect they started taking it for impotence and found that it had other benefits, too, but bodybuilders are not the kind of guys who will admit impotence." Why Viagra Might Be an Effective Bodybuilding Drug

Viagra (sildenafil) is one of three FDA-approved, erection-promoting drugs called PDE-5 inhibitors that also include tadalafil (Cialis) and vardenafil (Levitra). They work by inhibiting the PDE-5 enzyme, which then increases the concentration of a chemical called nitric oxide that promotes blood flow to the penis and other tissues throughout the body. Blood vessels, smooth muscle, skeletal muscle, blood platelets, and lung tissue contain this and similar PDE enzymes. In addition to promoting erections, PDE-5 inhibitors decrease systemic blood pressure, lung blood pressure, lung resistance, and promote coronary (heart) blood flow. Long-term use improves endothelial function, which is critical to blood flow control.

The drugs reduce stress in pressure-overloaded hearts, which is important for bodybuilders because large increases in muscle tension restrict blood flow to working muscles. Increasing muscle blood flow during training could increase muscle strength, size, and fitness, while reducing stress on the heart. They also improve lung blood flow and boost quality of life in patients suffering from lung disease. These drugs have promising pulmonary and cardiovascular applications that go beyond firm erections.

To date, no study has found that Viagra improves exercise performance in athletes at sea level. The drug is helpful in people with blood pressure limitations that interfere with oxygen transport to the tissues. For example, lung blood pressure increases substantially in some people at altitude, which makes it difficult to move oxygen from the air into the bloodstream. Viagra reduces lung blood pressure, which enhances oxygen consumption and the capacity to exercise.

A small percentage of elite endurance athletes have a performance imbalance between the heart and lungs. Their powerful hearts exceed breathing capacity, which causes a mismatch between the pulmonary and cardiovascular systems. Viagra might increase lung function to match their superior heart capacity, which could give them a significant competitive advantage. However, other athletes might benefit as well.

Physical inactivity, diets high in saturated and trans-fats and simple sugars, and reduced muscle mass impair the ability of insulin receptors to regulate carbohydrates, amino acids (building blocks of proteins) and fats. Insulin sensitivity affects the health of the endothelium, the cells that line the blood vessels. These cells release nitric oxide (NO) that opens blood vessels in tissues throughout the body. Long-term use of Viagra has training-like effects on the endothelium, which increases its capacity to release NO. While the Viagra-induced improvements in blood flow control might be greater in men suffering from poor metabolic health, they might also promote blood flow in the muscles and nervous systems in bodybuilders and physically fit adults. Viagra doesn’t appear to increase endurance performance following short-term use, but it might have long-term benefits in well-trained athletes.

Long-term use of Viagra might also benefit metabolic capacity by enhancing blood sugar control and increasing testosterone levels. Scientists from Vanderbilt University School of Medicine found that the drug helped restore energy balance and boosted insulin metabolism in mice fed high-fat diets (compared to a placebo). The animals showed lower blood sugar and insulin levels and improved blood sugar regulation after a high-carbohydrate meal. They also lost bodyweight and fat mass during the 12-week study. In humans, long-term use of Viagra increased the production of the blood vessel controlling chemical nitric oxide, which has strong links to insulin metabolism.

Viagra boosts testosterone, which is a critical hormone for increasing muscle mass, strength, and aggressiveness— all critical for athletes. Testosterone is linked to sexual arousal and performance. Middle-aged men who take testosterone supplements improve sex drive, capacity for erections, self-confidence, and aggressiveness. Italian researchers found that total and free testosterone levels increased by 50 percent in men treated for erectile dysfunction with Cialis or Viagra. It’s not clear whether these drugs increased testosterone directly or if they increased it indirectly through increased sexual activity. Frequency of sexual intercourse was greatest in men who took Cialis (a longer-acting PDE-5 inhibitor), which makes it the preferred drug for men in stable relationships. Men who had the most sex also had the highest testosterone levels.

Factors affecting testosterone include psychological health, diet, exercise, and sexual activity. Men who have a lot of sex are happier, more confident, and have better-functioning sex organs than men who don’t. The sex organs— like your muscles— function best when you use them, so Viagra might give them a boost. We don’t know if Viagra increases testosterone levels in healthy, fit bodybuilders.

Long-term use of Viagra might also increase muscle strength, power, and size by triggering biochemical pathways that increase protein synthesis and prevent protein breakdown in muscle cells. As discussed, Viagra increases nitric oxide (NO) release by the blood vessels. NO helps turn on protein synthesis in muscles, particularly when the fibers are under tension or stretch. NO also triggers the formation of satellite cells that add mass to the muscle fibers. To date, no study has shown that Viagra and similar drugs have steroid-like effects in athletes, but we can infer from biochemical studies that they might.

Wednesday, December 10, 2014

Effect of Nandrolone

According to the International Union of Pure and Applied Chemistry (IUPAC) system of nomenclature, the anabolic steroid has the name 17b-hydroxy-19-nor-4-andro-sten-3-one, and can occur naturally in the body, albeit in minute quantities. Structurally, it's very similar to Testosterone, the male hormone that was recently the buzz word in sports bulletins after Floyd Landis, the Tour de France winner, tested positive for excessive levels. Nandrolone is a modification of testosterone (carbon atom removed from the 19th position). With an Anabolic/Androgenic ratio: 125:37, meaning it is highly anabolic (muscle building) and moderately androgenic (male characteristics). Due to Nandrolones chemical structure it only aromatizes (converts to estrogen) slightly, at about 20% the rate of testosterone when it interacts with the aromatase enzyme. Ergo, estrogenic effects are not a major concern with its use. Of note, however, is that Nandrolone is a progestin with a binding affinity of 20% to the progesterone receptor (PgR), so side effects are still possible, though rare. One of the most popular anabolic steroid used in bodybuilding cycles, Nandrolone is also (medically) used to treat severe debility or disease states and refractory anemias. It promotes tissue building processes, reverses catabolism (muscle destruction) and stimulates erythropoiesis (red blood cell production). This makes it a very useful drug to treat wasting disorders such as advanced H.I.V. and also, makes it highly sought after by bodybuilders and athletes.

Nandrolone is most commonly found with a Cypionate, Decanoate or plenylpropionate ester. Briefly explained, the ester determines how much of the given hormone is released over a period of time. Longer esters such as Decanoate peak slowly and can keep stable blood plasma levels up to ten days, shorter esters such as the phenylpropionate peak more rapidly but the half-live is shorter. Shorter esters usually release much more active hormone per mg than longer esters, and of course, allow the drugs effects to leave your system more quickly. Surprisingly NPP (Durabolin) and ND (Deca) release almost the same amount of active nandrolone per 100mgs: 69% and 65% respectively; this does not correlate exactly though because blood levels of Nandrolone are much higher (about doubled) post NPP usage compared to the same 100mg dose of ND. NPP also has more distinct advantages over ND. One of the most common complaints about adding ND (Deca) to a cycle is the water retention that accompanies its use. Gains from NPP are reported to be "clean" with minimal water retention and fat gain. While ND is usually used in "bulking" cycles, NPP is used in "cutting" cycles although either drug can be used in either regard. Being an oil based anabolic it is injected intramuscular (into the muscle), many users inject it ED or EOD, however NPP can administered E4D without problems.

NPP and Nandrolone in general, has a number of benefits for athletes, it increases levels of serotonergic amines in the brain, these chemicals contribute to aggressive behavior, this could help athletes to train harder and improve speed and power. Nandrolone also increases levels of IGF-1 in muscle tissues. This may be another way that makes Nandrolone highly anabolic. NPP also benefits the athlete by increasing the number of androgen receptors (AR) one study showed that nandrolone given to rats at a dosage of 6mg/kg of body weight combined with muscle functional overload (muscle functional overload gives a similar effect to resistance training) had a 1,300% increase in AR protein concentrations. There is a direct link to muscle growth and AR levels. NPP also seems to be a promising fat loss agent, men given the drug had reduced levels of subcutaneous (under skin) adipose(fat) tissue, visceral (gut) fat loss was not as good however. The fat loss effect seems though to be dose dependant, in one study NPP at a daily dose of or 10mg per kg of body weight the 10mg dose had the greatest effect on fat loss, thus displaying a dose respondent curve with NPP. The more you use, the more results you'll get, with regards to this drug.

NPP is used to treat anemia by stimulating red blood cell production and an increase in RBC count can improve endurance during exercise via better lactic acid clearing and oxygen delivery. The blood is also better enabled to carry nutrients to muscle tissue to aid in repair, administration also increases the rate of muscle glycogen repletion after exercise helping the athlete dramatically improve recovery after strenuous physical exercise. Athletes who require a high level of endurance in their chosen sport can benefit from the use of NPP. A favorite with bodybuilders who suffer with sore joints, NPP can also improve collagen synthesis, which may improve joint function and alleviate joint pains.

Nandrolone Side Effects:
Although many Nandrolone lovers claim that it is one of the safest anabolic steroids, if not the safest. It does have side effects that can be bothersome in hypersensitive individuals, such as acne, excitation, insomnia, nausea, diarrhea and bladder irritability. More serious (and common) side effects include testicular atrophy (shrunken balls), impotence and gynecomastia. Nandrolone use has been shown to be safe and easy on the lipid profile, often improving HDL Cholesterol. Impotence can be offset by stacking the Nandrolone with a higher testosterone. Nandrolone also causes the "shut down" (total stoppage) of endogenous (natural) testosterone production. Thus an exogenous (outside) source must be provided, the increased prolactin levels from the use of a progestinic steroid contribute to HPTA shut down and testicular atrophy which can be treated with a combination HCG (a female hormone that acts like LH when introduced into the male body) and Bromocriptine (a dopamine receptor agonist that, among other things, can lower prolactin levels.) Besides using Bromcriptine to lower prolactin levels, the anti-estrogens Fulvestrant or Letrozole on be taken to down regulate the progesterone and estrogen receptor.

Wednesday, December 3, 2014

The Therapeutic Effects of Deca Durabolin

The effects of Deca Durabolin lead this to be one of the most beneficial anabolic steroids any man will ever use. This steroid carries an extremely high level of toleration, it is one of the best anabolic steroids for the promotion of lean muscle mass, and its therapeutic benefits cannot be ignored.

The effects of Deca Durabolin can lead to tremendous promotions in lean muscle mass. However, this is not a magical hormone; you must eat to fuel such growth. In order to grow you will need to consume excess calories. If this excess intake goes too far body fat can get out of control. Most will only need a slight increase above maintenance, but the precise increase will vary from man to man. Once the proper caloric intake is found, the effects of Deca Durabolin will enhance tissue growth. This is largely accomplished by the steroid’s ability to enhance protein synthesis and IGF-1 production. The individual should also find he gains less body fat during the off-season than without the use of this steroid due to the positive effect training and enhanced hormonal levels can have. While the effects of Deca Durabolin on mass promotion are strong, we must understand they will not occur overnight. This is not a fast acting steroid, and while it can produce significant gains it will not promote a total weight increase as great as some steroids. However, it’s important to remember weight is meaningless; while some steroids will promote remarkable weight gains, such gains are often largely water retention. The effects of Deca Durabolin can lead to water retention, but this is very easy to control. The use of anti-estrogens will go a long way, but a proper diet will also help. Many who hold more water than they should often blame the steroid, but in many cases, the problem is often their diet. If you overeat excessively, especially carbohydrates, you will hold water. This will hold true with or without anabolic steroid use. However, with an aromatizing steroid this can enhance the issue. Control your diet, control estrogen and display consistency with your training and the effects of Deca Durabolin will provide high quality growth. In fact, many will find the gains made through this steroid’s use are much easier to hold onto compared to many anabolic steroids.

The effects of Deca Durabolin during the cutting phase can be extremely beneficial. This steroid will not provide strong conditioning effects, but that doesn’t mean it doesn’t have a place in a cutting cycle. Due to its traits, especially the promotion of nitrogen retention, this is an excellent steroid for the preservation of lean tissue. In order to lose body fat, we must burn more calories than we consume and this puts lean muscle tissue at risk. Regardless of how well planned your diet is, some lean tissue will be lost if an anabolic protectant is not present. In successful dieting, it can only be deemed successful if body fat is lost while simultaneously maintaining as much lean tissue as possible. The effects of Deca Durabolin will enable the individual to meet this success. This is not the only benefit the effects of Deca Durabolin will present during this phase. The therapeutic benefits of this steroid are tremendous, and that’s exactly what we want to discuss next. Regardless of your purpose of use, the effects of Deca Durabolin surrounding therapeutic relief are tremendous. Many anabolic steroids have the ability to promote enhanced collagen synthesis and bone mineral content, but the Nandrolone hormone tends to take it to a high level. This is why many report tremendous joint pain relief when using this steroid. Due to these factors, as well as other traits discussed, total recovery is also greatly enhanced. Lean tissue is repaired at a faster and more efficient rate. Studies have shown the effects of Deca Durabolin may also be very beneficial to the healing of ligaments and tendons as well.

When considering the therapeutic effects of Deca Durabolin, it’s important to understand we’re not referring to masking like effects. We’re not talking about masking effects provided by painkillers or related medications, we are talking about true healing and therapeutic relief. Bulking or cutting there is no athlete who will not benefit from these effects of Deca Durabolin. In fact, many athletes who are not bulking or cutting at all find low doses of this steroid to be extremely beneficial for the therapeutic relief it can provide.

The effects of Deca Durabolin on endurance, particularly muscular endurance, can be more than significant. The individual will not tire out as fast; his muscles will not wear down under strenuous activity as quickly. The Nandrolone hormone is not well-known for promoting increases in strength, but the individual should be able to maintain a higher level of strength for a longer period of time due to this hormone’s use. This is in part due to the effect of Deca Durabolin on red blood cells. The Nandrolone hormone will greatly increase red blood cell count, which will provide greater blood oxygenation. With the enhancement of protein synthesis, nitrogen and IGF-1 and the reduction in glucocorticoid hormones this steroid provides, muscular endurance is enhanced all the more.