Wednesday, November 26, 2014

Proviron orally effective androgen

Proviron is a synthetic, orally effective androgen which does not have any anabolic characteristics. Proviron is used in school medicine to ease or cure disturbances eaused by a deficiency of male sex hormones. Many athletes, for this reason, often use Proviron at the end of a steroid treatment in order to increase the reduced testosterone production. This, however is not a good idea since Proviron has no effect on the body's own testosterone production but-as mentioned in the beginning-only reduces or completely eliminates the dysfunctions caused by the testosterone deficiency. These are in particular impotence which is mostly caused by an androgen deficiency that can occur after the discontinuance of steroids, and infertility which manifests itself in a reduced sperm count and a reduced sperm quality. Proviron is therefore taken during a steroid administration or after discontinuing the use of the steroids, to eliminate a possible impotency or a reduced sexual interest. This, however does not contribute to the maintenance of strength and muscle mass after the treatment. There are other better suited compounds for this. For this reason Proviron is unfortunately considered by many to be a useless and unnecessary compound.

You should be aware that Proviron is also an estrogen antagonist which prevents the aromatization of steroids. Unlike the anti estrogen Nolvadex which only blocks the estrogen receptors (see Nolvadex) Proviron already prevents the aromatizing of steroids. Therefore gynecomastia and increased water retention are successfully blocked. Since Proviron strongly suppresses the forming of estrogens no rebound effect occurs after discontinuation of use of the compound as is the case with, for example, Nolvadex where an aromatization of the steroids is not prevented. One can say that Nolvadex cures the problem of aromatization at its root while Nolvadex simply cures the symptoms. For this reason male athletes should prefer Proviron to Nolvadex. With Proviron the athlete obtains more muscle hardness since the androgen level is increased and the estrogen concentration remains low. This, in particular, is noted positively during the preparation for a competition when used in combination with a diet. Female athletes who naturally have a higher estrogen level often supplement their steroid intake with Proviron resulting in an increased muscle hardness. In the past it was common for bodybuilders to take a daily dose of one 25 mg tablet over several weeks, sometimes even months, in order to appear hard all year round. This was especially important for athletes appearances at guest performances, seminars and photo sessions. Today Clenbuterol is usually taken over the entire year since possible virilization symptoms cannot occur which is not yet the case with Proviron. Since Proviron is very effective male athletes usually need only 50 mg/day which means that the athlete usually takes one 25 mg tablet in the morning and another 25 mg tablet in the evening. In some cases one 25 mg tablet per day is sufficient. When combining Proviron with Nolvadex (50 mg Proviron/day and 20 mg Nolvadex/day) this will lead to an almost complete suppression of estrogen.

The side effects of Proviron in men are low at a dosage of 2-3 tablets/day so that Proviron, taken for example in combination with a steroid cycle, can be used comparatively without risk over several weeks. Since Proviron is well-tolerated by the liver liver dysfunctions do not occur in the given dosages. For athletes who are used to acting under the motto "more is better" the intake of Proviron could have a paradoxical effect. The most common side effect of Proviron-or in this case, secondary symptom- is in part a distinct sexual overstimulation and in some cases continuous penis erection. Since this condition can be painful and lead to possible damages, a lower dosage or discontinuing the compound are the only sensible solutions. Female athletes should use Proviron with caution since possible androgenic side effects cannot be excluded. Women who want to give Proviron a try should not take more than one 25 mg tablet per day. Higher dosages and periods of intake of more than four weeks considerably increase the risk of virilization symptoms. Female athletes who have no difficulties with Proviron obtain good results with 25 mg Proviron/day and 20 mg Nolvadex/day and, in combination with a diet, report an accelerated fat breakdown and continuously harder muscles. In clinical situations Proviron is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level. Proviron can usually reverse problems of sexual disinterest and impotency, and it is sometimes used to increase the sperm count. Proviron does not stimulate the body to produce testosterone, but mesterolone is simply an oral androgen substitute that is used to compensate for a lack of the natural male androgen. Although mesterolone is strongly androgenic, the anabolic effect of Proviron is considered too weak for muscle building purposes.

Wednesday, November 19, 2014

What causes testosterone deficiency?

Low testosterone can be confirmed with blood tests which a GP can arrange for the sex hormones testosterone, luteinising hormone (LH) and follicle stimulating hormone (FSH). Additional tests may be needed as hormone levels vary across the day. Treatment may not be recommended if low testosterone is diagnosed but troublesome symptoms are not being experienced.

Treating low testosterone: If low testosterone is diagnosed, the missing hormones can be replaced with hormone replacement therapy to bring the body’s testosterone levels back to normal. This should remove symptoms of hypogonadism and related sexual problems. Testosterone replacement therapy can be given in different forms. A doctor will discuss the different options before deciding which one is most appropriate. Testosterone levels may need to be checked after treatment begins so the right dose can be given.
Testosterone replacement therapy options

Injections: Regular injections are given deep into a muscle, called intramuscular injections. Depending on the type of injection recommended, these can be every two to three weeks to every three months. These may be injected by a doctor or practice nurse, self-injected or done by a partner. Carried out correctly, these shouldn’t be too painful.

Cylindrical pellets are inserted in the abdomen, buttock or thigh by a doctor under local anesthetic once every three to six months.
Capsules: These are swallowed on a daily basis but give a lower dose of hormones than other methods.
Patches: These work similar to nicotine patches for people trying to quit smoking and deliver testosterone gradually through the skin using a new patch each day.

Gum or buccal testosterone: Testosterone gum is put in the mouth above the front teeth.
Testosterone gel: Gel is applied to the skin, usually on the shoulder, arm or abdomen. This need to be used after showering to stop it washing off too soon.
Testosterone is an important sex hormone. It's a type of hormone called an androgen. You may hear testosterone described as a male hormone. But women also make testosterone, although they make much less of it. In women, testosterone is made mostly by the ovaries, although some is also made by the adrenal glands. Testosterone gives men their male characteristics, such as facial hair and a deep voice. It also triggers sexual development and helps the growth of muscles and bones. Testosterone can also be used as a treatment. It can help start puberty in boys who are very late in developing. Testosterone can also be used to treat symptoms of the menopause. Doctors don't often prescribe it, but they may do if a woman is worried about her loss of sex drive. Testosterone may increase sexual desire and arousal in women going through the menopause. It's usually prescribed in addition to hormone replacement therapy (HRT). For the menopause, you normally have testosterone as an implant (a small pellet put under your skin). Testosterone also comes as capsules (Restandol), a skin patch (Intrinsa) and injections.

If low testosterone is diagnosed as causing a man's erectile dysfunction, hormone replacement therapy may be recommended. Testosterone is a hormone produced by the testicles and is responsible for the proper development of male sexual characteristics. Testosterone is also important for maintaining muscle bulk, adequate levels of red blood cells, bone growth, a sense of well-being and sexual function.

As a man ages, the amount of testosterone in his body gradually declines. This natural decline starts after age 30 and continues throughout life. Other causes of lowered testosterone levels include:

    Injury, infection or loss of the testicles
    Chemotherapy or radiotherapy treatment for cancer
    Genetic abnormalities such as Klinefelter’s syndrome (extra X chromosome)
    Haemochromatosis (too much iron in the body)
    Dysfunction of the pituitary gland (a gland in the brain that produces many important hormones)
    Inflammatory diseases such as sarcoidosis (a condition that causes inflammation of the lungs)
    Medications, especially hormones used to treat prostate cancer and corticosteroid drugs
    Chronic illness
    Chronic kidney failure
    Liver cirrhosis

The significance of testosterone decline is controversial and poorly understood. Without adequate testosterone a man may lose his sex drive, experience erectile dysfunction, feel depressed, have a decreased sense of well-being and have difficulty concentrating.

What changes occur in the body due to testosterone deficiency:

    Decrease in muscle mass, with an increase in body fat
    Decrease in hemoglobin and possibly mild anemia
    Fragile bones (osteoporosis)
    Decrease in body hair
    Changes in cholesterol levels and lipid levels

The only accurate way to detect the condition is to have your doctor measure the amount of testosterone in your blood. Because testosterone levels fluctuate throughout the day, several measurements will need to be taken to detect a deficiency. Doctors prefer, if possible, to test levels early in the morning since this is when testosterone levels are at their highest.

Tuesday, November 11, 2014

What is Mechano Growth Factor?

Mechano Growth Factor (MGF) also known as IGF-1Ec is a growth factor/repair factor that is derived from exercised or damaged muscle tissue.  It’s called MGF as IGF-IEa is a bit of a mouthful and harder to identify amongst the other IGF variants. What makes MGF special is its unique role in muscle growth.  MGF has the ability to cause wasted tissue to grow and improve by activating muscle stem cells and increasing the upregulation of protein synthesis, this unique ability can rapidly improve recovery and speed up muscle growth.  MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-1 receptor domain which, in turn, increases protein synthesis turnover; therefore, if used correctly it can improve muscle mass over time.

The liver produces 2 kinds of MGF splice variants of IGF:
1) IGF-1Ec: This is the first phase release igf splice variant and it appears to stimulate satellite cells into activation, This is the closest variant to synthetic MGF.
2) Liver type IGF-IEa: this is the secondary release of igf from the liver, and its far less anabolic.
MGF differs from the second variant IGF-IEa as it has a different peptide sequence which is responsible for replenishing the satellite cells in skeletal muscle, in other words, it is more anabolic and longer acting than the systematic release of the second MGF liver variant.

So just think of MGF as a highly anabolic variant of igf.  After you have trained, the IGF-I gene is spliced towards MGF then that causes hypertrophy and repair of local muscle damage by activating the muscle stem cells as well as other important anabolic processes, including the above mentioned protein synthesis, and increased nitrogen retention. In rats, some studies have shown muscle mass increases of 20 percent from a single MGF injection, but  somehow  many of these studies are not accurate, however the potential is undeniable.

When you train, what happens to your muscles is they break down, the cells are damaged, muscle tissue needs to be repaired and your body produces 2 forms of MGF splice variant.  The first initial release of the above mentioned number 1 variant from the liver helps muscle cell recovery, if there is no MGF then muscle cells die.

As muscle is a post-mitotic tissue and as such cell replacement is not a means of tissue repair, if the cells are not repaired they die and your muscles get smaller and weaker.  In muscle tissue, the pool of these stem cells is apparently replenished by the action of MGF, which is produced as a pulse following damage.

Now, with synthetic injections of MGF you can increase the pulse and so speed up recovery, and increase the muscle tissue cells by stimulating satellite cells into full maturity. In terms of dosages, 200mcg bi-laterally is the very best choice of dosing in muscles trained.

The only problem with MGF, and this is the reason is that it has such a short half life, just a few minutes, between 5-7, and it needs to be used immediately post workout as it wont work if muscle tissue hasn’t been damaged.

Nevertheless, MGF has a huge role to play, and is administered to those with muscle wasting diseases and for those who are elderly and have lost muscle mass for good reason, it is extremely anabolic. What is PEG MGF (pegylated mechano growth factor)?

MGF that’s pegylated, which means it has the addition of Polyethylene glycol – a non toxic additive that increased the half life of MGF from minutes to hours.  This means its uses and versatility make it a tremendous addition to a bodybuilders arsenal. The next aspect we need to look at is how to make the most use of a long acting version of MGF.

When your muscle is damaged, your body releases a pulse of an MGF splice variant as I outlined above, followed by a less anabolic longer acting version from the liver.  Therefore, it seems a waste to inject MGF at this time as you will just blunt your body’s own release, your not enhancing it.  So using PEG MGF on non workout days is actually the best route.  Since the muscle has been damaged, there are plenty of receptors for MGF, and the effects are systematic.  All muscles will be aided in recovery through increased nitrogen retention, protein turnover, and satellite cell activation.  Recovery is just going to sky rocket.  Doing this means you’re increasing the length of your body’s own mechanism for muscle repair and growth, and you’re opening up the anabolic window.

Running PEG MGF in synergy with IGF is perfect but there are things you need to know.  Since IGF has such strong receptor affinity, if you dose them at the same time, the effectiveness of MGF will just be wasted, at least on paper (the science supports this claim).  However,  IGF DES on workout days pre-workout, or IGF1-LR3, this wont blunt your body’s own MGF release from the liver. Whereas IGF1-LR3 has a more systematic effect and only a very small localized anabolic effect, DES on the other hand is very anabolic in a localized way.  Therefore, bring up lagging muscle parts with DES, and then the following day Dose MGF at 200-400mcg to increase recovery and the mechanism for growth. Perfect synergy.

Over a 4 week run, noticed about 4lb increase with the PEG MGF and LR3 partnership, and roughly the same weight in fat loss, very impressive.  Though, some of my clients have noted far greater increases in muscle mass.  If you’re on a steroid cycle, there is no need for the addition of DES as IGF levels will already be elevated; you’re better off with MGF, PEG MGF can take your recovery and gains to a new level. MGF and IGF-1 LR3 can be used as a bridge between steroid cycles and during PCT to prevent muscle loss and speed up recovery. Dosing 3 times a week as suggested above, and 1ml of BA water for every 2mg is optimal.  Storage in the fridge for up to 6 months.

Tuesday, November 4, 2014

Bodybuilding and causes of impotence

Bodybuilding and fitness play a huge role in sex. Some women report a burst of energy after an orgasm. Sex increases a man's overall production of testosterone. Men are stereotypically notorious for bawdy locker room talk; women, body parts, certain unmentionable deeds, and normally as women we roll our eyes and pretend to be offended at the utter lack of class they must have.

Women however, may not share their immediate thoughts to everyone about sex and other formerly thought-to-be taboo issues as readily. Competitive bodybuilders and fitness athletes are no different, but it all seems to revolve on how the sex, or lack thereof will affect their training, their dieting, their physique, and in the end, their placing. It is well known that many professional athletes, baseball players, football players, fighters, and endurance athletes have all claimed to abstain from sexual activity with a partner, and even from masturbation immediately before a big event. There is this 'old-school' belief that it somehow reduces stamina, reduces power, and reduces the force that the athlete can put forth at their big event, tournament or game.

This seems to be true, for a minute. After athletes abstained from ejaculation (serum test levels were tested daily) for 6 days their levels had not changed. On the seventh day only, the levels of testosterone jumped by 50 percent. It's true that bodybuilding (lifting weights that is) lowers testosterone levels (serum), but only remain slightly lower for less than 3 hours. One study found that when 10 men watched a pornographic movie for 15 minutes, their testosterone levels jumped 100 percent afterwards, while the 10 ladies rolled in at 80 percent more testosterone. Now should we all watch porn right before we hit the gym well, maybe not every workout! Seriously though, the arousal itself seems to show a massive increase in test levels, and it would then seem the next question to be, "How long does it last?"

It seems the levels remained elevated at 75 percent of the max for over 90 minutes, so you better hurry! From the other side of the coin this also seems to increase aggression in turn, and increases the likelihood one will do things such as pull the trigger on a gun. For men, bodybuilding offers a few more benefits aside from increased body image and self-esteem. It also increases their overall production of testosterone over a long period of consistent training and its known that men's testosterone levels can begin to decline as early as 25 years old.
The action of lifting weights, for reps, for one hour or more, increases vasodilatation throughout the body, and when a man is a smoker, or has arterial disease in his family, this can affect erections, as the lack of blood flow to the area will eventually cause impotence. Over a long period of time and frustration, it's nice to know that it can possibly be a helpful benefit to those with that issue. Not to mention the increased strength can aid in a vast supply of new sexual positions you and your partner would both appreciate.

Impotence is a condition that affects the male, and is medically referred to as ED or Erectile dysfunction. There are various reasons that studies indicate as causes of this problem in men. The main symptom of this problem of male impotence is the recurring or persistent inability of a male to be able to achieve an erection and also to maintain an erection in spite of the person having a high desire for sex. This erection is required for concluding any sexual act or sexual contact. Some of the main causes of impotence in a man include some kind of damage to either the arteries or the smooth muscles. It also includes damage to the man’s fibrous tissues.

Other major causes of impotence include disease. There are certain diseases like diabetes, chronic alcoholism, kidney disease that can be a major cause of impotence in men. Even diseases like multiple sclerosis, vascular diseases and atherosclerosis are a cause of impotence in a large number of men. For some men, taking harsh and strong medications like certain antibiotics could be a major source of impotence. There are certain drugs, tranquilizers and antidepressants that are also a cause of this condition. Even appetite suppressants and antihistamines can cause problems. Stress is considered to be one of the biggest causes of impotence or erectile dysfunction. Work stress or stress at home needs to be reduced to help a man to regain his sexual behavior. At times there are certain psychological factors which are big contributors too. Some of these include low self-esteem, anxiety, depression and even guilt. For some just a fear of failure sexually is enough to cause this problem. For different people this problem can vary. For some it might mean the total inability to ejaculate or to even get an erection. For some it might mean simply getting very brief and short erections. There is no clear cut test to help a man confirm if he is suffering from this problem. This problem would need to be professionally determined and addressed to help a man get some relief or to find a cure for this problem. One can try some simple home remedies to help in dealing with this problem. These include eating garlic. One could try eating about 2 to 3 cloves of garlic on a daily basis. One should include plenty of garlic in their regular diet.