However, most bodybuilders are not concerned with the question: how to increase potency, but the drug they use for Pumping. The fact is that the active ingredient of Viagra (Sildenafil), enhances blood flow to muscles, which increases endurance thereby to achieve good results.
Bodybuilder can lift more weight, perform more reps with and approach than usual. Thus, coefficient useful weight training increases, thanks to the more intense muscle groups. opinion that Viagra is another donor of nitrogen. Currently, the organization that fights against doping explores the drug Viagra on athletic performance. If in the course of the experiments will still be shown that Viagra has a great contribution to athletic performance, the drug will be banned in speed and power sports. Bodybuilding such bans probably will not be threatened, as Viagra has no adverse impact on health. With minimal adverse events Viagra also has a positive effect on the heart, improves circulation and slightly reduces blood pressure.
Favorably to steroids and anabolic steroids, Viagra has no effect on the human body is harmful. It should be noted that an erection when using the drug only appears to stimulate sexual arousal. Another very popular among bodybuilders drug – Cialis. The active substance is analogous to the Cialis (Tadalafil), Sildenafil (Viagra). Blood flow to muscle is dramatically increased during high intensity exercise. The increase in blood flow serves to enhance the delivery of oxygen to active muscle cells and to increase the removal of lactate. This phenomenon is all too familiar to bodybuilders. Viagra (Sildenafil Citrate): a refresher cours. Rest assured, this won’t happen. Sildenafil, at recommended doses, has no effect on erectile tissue in the absence of sexual stimulation. If you don’t normally find yourself sporting a woody as you step out on stage, you have nothing to worry about. Besides, you can always experiment before hand so you know what to expect (e.g. blood pressure changes). Now, back to the science of this little blue pill. Viagra is the citrate salt of Sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE5). A phosphodiesterase is a phosphatase (as from snake venom) that acts on diesters (like some nucleotides) to hydrolyze only one of the two ester groups. In target cells, phosphodiesterase acts to hydrolyze cGMP and cAMP into inactive fragments, thus shutting down the second messenger cascade. A phosphodiesterase-inhibitor is a molecule that inhibits the action of phosphodiesterase. This allows cGMP (or cAMP depending on the type of phosphodiesterase) to remain in active form and thus extends or prolongs the activity of the cascade. This is part of the rationale for using caffeine, a well-known phosphodiesterase-inhibitor, with ephedrine. In working muscles, nitric oxide (NO) activates the enzyme guanylate cyclase, which results in increased levels of cGMP, producing smooth muscle relaxation of blood vessel walls. This causes vasodilation. Sildenafil has no direct relaxant effect on smooth muscle alone, but enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP. For example, when hypoxia and/or lactate formation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the blood vessels, resulting in vasodilation. Once again, Sildenafil at recommended doses has no effect on penile tissue in the absence of sexual stimulation. Keep in mind that Sildenafil does not change the way lifting weights causes muscle pump either, it only enhances it.
There are several reasons why the pump you get back stage is far from dramatic. Getting a good pump depends in large part on lactate formation by the working muscles. As your muscles are forced to work anaerobically, lactic acid is formed triggering a series of signals that dilate blood vessels leading to the muscle. A muscle adapted to caloric restriction shifts its preferred fuel from carbs to fatty acids and ketones, neither of which generates lactate when used for fuel. So while training on a low calorie and especially a low carb diet, lactate induced muscle blood flow is reduced compared to normal well-fed conditions. On the day of the show you want to look lean but with full muscle bellies. The only way to do this is to be in a state of good hydration, loaded with glycogen, have restored muscle triglyceride levels, and have a decent pump when you step on stage for the morning prejudging. Hydration, glycogen and muscle triglycerides will have to wait for another time, but getting a pump just got a little easier. Because NO triggers vasodilation in skeletal muscle vasculature, Viagra will increase the ability to get and maintain muscle pump by inhibiting PDE-5 production